Promethazine hydrochloride and codeine phosphate syrup is indicated for that short-term relief of coughs and higher respiratory indicators related with allergy or perhaps the typical chilly.
Promethazine with Codeine Oral Solution is a combination of codeine, an opioid agonist; and promethazine, a phenothiazine, indicated to the non permanent aid of cough and upper respiratory indications connected with allergy or perhaps the common cold in individuals eighteen years of age and older.
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Get medical assist without delay should you notice any of the following: gradual/shallow respiration, extreme drowsiness/issues waking up, confusion.
Always use an accurate milliliter measuring unit when administering Promethazine with Codeine Oral Solution to make certain that the dose is calculated and administered properly. A home teaspoon is not really an accurate measuring product and could lead to overdosage [see Warnings and Precautions ( five.seven)]. For prescriptions the place a measuring gadget will not be delivered, a pharmacist can provide an suitable measuring product and can provide Recommendations for measuring the right dose. Don't overfill.
To scale back the chance of dizziness and lightheadedness, get up slowly but surely when mounting from a sitting or lying situation.
If somebody has overdosed and has major signs and symptoms for example passing out or hassle respiratory, get in touch with 911. If not, simply call a poison Regulate Middle instantly.
The concomitant utilization of opioids with other medicine that impact the serotonergic neurotransmitter process has resulted in serotonin syndrome.
Critical, lifetime-threatening, or deadly respiratory melancholy is documented with the use of opioids, such as codeine, among the list of Energetic components in Promethazine with Codeine Oral Remedy. Codeine creates dose-associated respiratory depression by directly performing about the brain stem respiratory center that controls respiratory rhythm and could develop irregular and periodic respiration. Codeine is topic to variability in metabolism based on CYP2D6 genotype, which can cause a heightened publicity into the Lively metabolite morphine [see WARNINGS AND PRECAUTIONS (5.3)]. Promethazine exerts a depressant effect on the respiratory center which is impartial of and additive to that of other respiratory depressants, which include codeine [see WARNINGS AND Safety measures (five.
You'll have respiration problems or withdrawal signs or symptoms if you start or cease having specific other medicines. Convey to your medical doctor more info if You furthermore may use specific antibiotics, antifungal medications, seizure medication, or medicines to treat HIV or hepatitis C.
Get this medication by mouth with or without foodstuff as directed by your physician, ordinarily each and every four to six hours as essential. This medication can be taken with foodstuff if tummy upset occurs. Drink loads of fluids whenever you use this medication Until otherwise directed by your medical professional.
To reduce your danger, your medical doctor should have you take the smallest dose that actually works, and choose it for that shortest attainable time. See also The way to Use area To find out more about dependancy.
“Medical doctor buying” (viewing many prescribers to get extra prescriptions) is popular between drug abusers and people struggling from untreated addiction. Preoccupation with achieving enough ache aid might be ideal habits within a affected individual with very poor discomfort Command.
Promethazine is metabolized via the liver to a range of inactive metabolites including sulfoxides of promethazine, N-demethylpromethazine along with other glucuronides.